Sir Alex's side saw a few changes with Van Persie, Young, Anderson and Rafael all getting the nod leaving Rooney on the bench after a dismal showing at Goodison Park.
The game kicked off with both teams looking to cash in the three points.While Fulham had displayed goal scoring prowess in their first game, but it was the home side who that had something to prove. But just as soon as United tried to take control of the game, Rafael gave away a free kick right at the edge of the box which was converted by Damian Duff to put the away side in the lead just three minutes into the game.
The Old Trafford crowd was silenced and it seemed as though all hope was lost and we would taste our second defeat. All those thoughts were simply eradicated when Robin Van Persie scored from Patrice Evra's cross. It was by all means an exquisite goal which saw the crowd go wild and was exactly what the team needed to push for the win.
United continued to attack with crisp passes and forward runs while the cottagers held their own and organized their defense to keep United at bay.It was at the 35th minute that Fulham finally cracked. Tom Cleverley drove a blistering shot towards goal which seemed to much for Schwarzer to handle who couldn't parry the ball away which saw Shinji Kagawa tap home a sitter to make it 2-1.
United were not done yet,and just six minutes later saw Rafael head home the third goal after a brilliant chipped pass by Ashley Young at the far corner. United looked to be cruising with the score 3-1 at the break.
The second half saw Manchester United take the pedal off the gas as they just passed and maintained possession but without breakthrough and in the 65th minute saw an unlikely goal which hit the heel of Vidic and headed straight for the back of his own net.
The goal certainly fired up the visitors notably when Moussa Dembele, who caused United problems the entire game, made space for himself and fired at goal forcing De Gea into a reaction save.
Sir Alex quickly added to the attack with the introduction of Rooney and Welbeck for Kagawa and Young having already played their part in the goals scored early on in the game. But Rooney's time on the field was limited after receiving a deep gash on his thigh due to Hugo Rodallega trailing boot leaving a subdued Old Trafford crowd coming to the end of the match.
Fulham still tried to grab a point in the dying minutes of the game with a powerful drive only for De Gea to parry it to safety which saw the game end with Manchester United coming out victorious.
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