Karagounis was a veteran of Greece's Euro 2004 winning side, scoring in their opening win against hosts Portugal, and even bagged the winner in their surprise win against Russia at Euro 2012.
While at 35 he showed just a couple of months ago he had what it took to contribute on the international stage, he did not feature in his country's opening World Cup 2014 qualifier at the weekend.
A new chapter? Perhaps, but his absence was more owing to the fact he has not been playing club football.
He made 29 appearances for Panathaniakos last season, but he has been unable to agree a new contract with the Greek side, with who he last won the league with in 2010.
As a result he is now a free agent and Fulham are said to be taking a look.
First the details; Despite registering their 25 man squad, the deal can happen. Fulham did not submit a full 25, and can make an application to the Premier League to add any new recruits. Each application will be considered on merit.
A similar scenario happened last season when Fulham took a chance on Mahamadou Diarra, who had been released by Monaco.
The Malian international has proved manager Martin Jol right to take a chance on him, and will give him encouragement that Karagounis can step in and have a similar kind of impact.
The Greek has played for Inter Milan and Benfica, and scored against Manchester United and Arsenal in Champions League matches. He is a man with immense experience which can only rub off well on the younger members of Fulham's midfield, and indeed squad.
Clearly at 35 he will only be a short-term option for the club, but as they strive to fill the void in central midfield left by the late departure of Moussa Dembele, Karagounis would be an excellent temporary solution.
The midfielder is a combative player, a fighter who works hard and has excellent technique to add to his experience. He is a goalscorer and match winner, and leader. All are qualities which don't come along on a potential free transfer too often, so if Fulham truly can close a deal, it would be well worth pursuing.
What do you think, is Karagounis a player Fulham should try to add to their squad?
image: © wjarrettc