Sir Alex Ferguson's side made an ideal start to the match after just eight minutes when captain Patrice Evra almost scored, but the Frenchman saw his shot smash against the crossbar.
Former Liverpool full-back John Arne Riise then forced Spanish keeper David de Gea in to a fine save as the let fly from 35 yards only to see his shot well saved.
The home side then came close once more as Bryan Ruiz created a chance but his shot hit the post and bounced to safety, before Brede Hangaland almost scored an own-goal down the other end.
Wayne Rooney was the next to be denied by the crossbar as he linked well with Robin Van Persie and the England international hit the post just minutes later with a superb curling effort.
Not only was the crossbar and upright denying an opening goal, Craven Cottage's floodlights didn't want one either as they failed two minutes before half-time.
However, quick work from the ground staff saw light and the game resumed, leaving Wayne Rooney to pick up where he left off, however, this time he would score and give his side the lead with 10 minutes remaining.
Van Persie had chance to make it 2-0 but he blasted his effort over the crossbar but United secured the three points and put themselves 10 points clear of Manchester City, who play Liverpool on Sunday.
image: © nasmac