Both sides have spent heavily in recent years, taking advantage of backing from Roman Abramovich and Sheikh Mansour respectively.
As a result, there will be world class players on the field, even in an FA Cup tie, despite both teams almost certainly prioritising their Premier League and Champions League commitments over Saturday's game. With that in mind, here is an XI made up of players from the two teams...
Goalkeeper: Petr Cech
Cech has been Mr. Consistency ever since he arrived at Stamford Bridge from Rennes in 2004, and has been fantastic yet again this season. Beats out Joe Hart simply because he's a more reliable stopper between the sticks.
Right Back: Pablo Zabaleta
Zabaleta is the perfect all-round full back, offering outstanding work rate to go along with his proficiency going forward and defending, which few full backs in the modern era can offer.
Centre Back: John Terry
Terry may be nearing the end of his career, but has been excellent for Chelsea this season. The 33-year-old has flourished under Jose Mourinho once again, and his making a strong case for a new contract at Stamford Bridge.
Centre Back: Vincent Kompany
The City captain is the best centre back in England. There aren't many that could even try and rival him for that tag. Strong, fast and with a great reading of the game, Kompany has been a pillar of Manchester City's recent success.
Left Back: Ashley Cole
Cole has struggled to play consistently this season, but he's still the most talented left back available here. Cole's athleticism has helped him become one of the world's great full backs, contributing heavily in attack and defence.
Central Midfield: Yaya Toure
Along with Kompany, Toure has been one of the faces of this Manchester City team in recent years. A driving force in midfield, Toure's ability to get forward and score goals is vital to the way City play, and is simply one of, if not the best midfielder in the Premier League.
Central Midfield: Nemanja Matic
Matic only returned to Stamford Bridge in January, but has already shown why Mourinho was so intent on bringing him back to West London. His composure in position coupled with his strength and ability to stop opposition attacks makes him the ideal holding midfield player.
Right Midfield: Eden Hazard
The man of the moment in the Premier League, Hazard is only just getting the plaudits for an outstanding season where he has been Chelsea's key man. Now adding more goals to his game, the sky is the limit for Hazard.
Left Midfield: David Silva
Silva has been another key cog of the City team, displaying touch, creativity and guile in possession. Most of City's attacks go through the diminutive Spaniard, and whilst he isn't much of a goalscorer, his importance can't be underestimated.
Forward: Alvaro Negredo
Negredo arrived from Sevilla in the summer having always looked suited to the Premier League, and his powerful style has been hugely effective under Manuel Pellegrini. With 23 goals in just 33 games, his £16m move looks like a bargain right now.
Forward: Sergio Aguero
Unsurprisingly, no Chelsea strikers make the team as Sergio Aguero rounds out the line-up. A true rival to Luis Suarez for the accolade of best striker in England, Aguero has been incredible this season, hitting 26 goals in 25 games.
image: © marc_tacoma