Reina, who won the 2006 FA Cup and 2012 League Cup during his time, will leave the Anfield club after nine years on their books after joining for around £6 million from Villarreal.
The Spanish goalkeeper made 394 appearances for the Reds and was an integral part of the side who consistently fought at the business ends of the Champions League and Premier League under Rafa Benitez.
However, as Liverpool's stock markedly dipped from 2010 onwards, so did Reina's, and the usually dependable stopper began to allow mistakes to blight his game as they ended with successive sixth, eighth and seventh finishes.
The arrival of Brendan Rodgers was the beginning of Reina's downfall at Anfield, and he becomes yet another victim of the Northern Irishman's ruthless streak.
Despite enjoying hero status amongst a large majority of the club's fans, Reina was moved on in cut-throat fashion as Liverpool signed Simon Mignolet for £9 million from Sunderland last summer, and the Spaniard hinted at a simmering discontent with his treatment by his manager when he departed for Napoli on loan.
In an open letter on his personal website, Reina sounded the death knell for his Liverpool career when he wrote: "If I have one regret, it is the way that I am leaving.
"It is only natural that I would be disappointed that the Liverpool management agreed to loan me to Napoli without telling me first, I thought that I deserved better than that even though I understand that difficult decisions have to be taken in football.
"A lot has been made about me informing the club that if an offer came in from Barcelona that I would have liked them to consider it."
His return to the club cut no ice with Rodgers, and when asked if his returning goalkeeper may be able to place pressure on Mignolet for the number one spot, he was unmoved.
"Pepe made it clear last year where he is at," he told the Liverpool Echo.
Speaking earlier this year, Rodgers made it crystal clear that a return would not be on the cards when he told reporters: “[Reina] wrote a goodbye letter didn’t he? I was surprised a loan player wrote a letter. I would suspect that he should come back but obviously Pepe made it very clear when he went to Napoli that he was looking to move.
"He penned a great big letter saying he was going to work with the best manager that he’d worked with and thanked us for his time for Liverpool. So for me it probably sounded like he’d made his decision there.”
Reina was one of the best-paid players at Anfield, and having a backup goalkeeper as one of the side's highest earners is simply foolish - Rodgers is wise to move him on, even for a sum as little as £2 million.
The 31-year-old will leave the club with fond memories and well wishes from the supporters, but the former Villarreal stopper joins the likes of Andy Carroll, Stewart Downing and Jonjo Shelvey as victims Rodgers' ruthless streak.
Carroll, Downing and Shelvey were all players who were unceremoniously dumped when better options became available to the Liverpool manager, and despite Reina's high-standing with the Anfield faithful, Rodgers also had no qualms about selling the Spaniard.