Tottenham should be looking at partnering this centre back with his international teammate Jan Vertonghen.
Tottenham are reportedly still in the market for a top international defender despite the Premier League opener with West Ham being round the corner. Toby Alderweireld may be that option, with the player's father admitting that the ex Ajax star is looking to leave Atletico this summer.
Were Spurs to firm up their interest in the centre back, they may face competition from other Premier League clubs, with Arsenal said to be interested too.
But despite the arrival of youngster Eric Dier, the promise of first team football at White Hart Lane would make a move an attractive option for Alderweireld.
The Belgium international only managed to make 22 appearances during Atletico's La Liga winning season, due to a combination of injury and the superb form of first choice central defenders Miranda and Diego Godin. Many of his appearances came deputising at full back, something he is capable of doing but almost certainly not where he'd choose to play.
Despite his stop-start season, Alderweireld featured prominently during Belgium's march to the World Cup quarter finals.
The 25-year-old's versatility is undoubtedly a bonus for any prospective club looking into signing him, with fellow Tottenham target Musacchio a centre back also capable of playing at right back, an area of the team Pochettino is said to be interested in strengthening this season ahead of DeAndre Yedlin's move next summer.
Signing Alderweireld offers significant advantages compared to any deal for the Villarreal's Argentinian defender.
Firstly, and most importantly, he has several years playing alongside Tottenham defender Jan Vertonghen, the only certainty in the Spurs defence. Pairing the two Belgians together, would see them rekindle their Ajax partnership, where for three years they played alongside one another, two of which saw the club win the Eredivisie.
Secondly, Alderweireld would likely cost much less than the rumoured £17 million quoted for Musacchio, a fee that will only increase as that initial bid was deemed too little. Atletico only signed the Belgian for around £7 million, and though they may make money on the defender, it should cost less than £15 million to sign him up.
And finally, Alderweireld would be joining a succession of Belgian central defenders that have all impressed in the Premier League were he to move to England. Vertonghen, Manchester City captain Vincent Kompany and recently departed Arsenal captain Thomas Vermaelen all settled into English football very quickly, enjoying superb debut seasons. Alderweireld, who with 37 international caps is also a more experienced player than the Argentine, should be able to adapt to Premier League life very quickly.
Who do you want Spurs to sign at centre back?