No two players seemed to make less of an impact against the Saints, mirroring a trend that fans are concerned applies more generally at Anfield.
Lucas gave the ball away time and again for Liverpool, while Johnson's place in the side will now be under pressure from Javier Manquillo and Jon Flanagan down the right-hand side - and Alberto Moreno and Jose Enrique down the left.
Is it time for Brendan Rodgers to cut his losses with a duo that are fast becoming the Kop's least popular players?
Here's how they rated in HITC's Player Ratings against Southampton...
"Lucas Leiva - 4/10
"Badly positioned for the goal and caught in possession far too often. Was given a chance today to show what he can offer Liverpool. In truth, he looks like he offers very little."
"Glen Johnson - 6/10
"Far from comfortable at left-back and his performances suggest Alberto Moreno has a strong chance of winning a place in the Liverpool team straight away."
A look at the statistics. meanwhile, makes for no less unpleasant reading for the pair.
|Team||Pos||Tackles Won||Interceptions Won||Challenges Lost||Apps||Mins|
As Opta stats show, Lucas and Johnson did not win a single tackle between them, though both lost challenges. At least they made a contribution interception-wise...
But if two interceptions per match is the sum of Lucas's game these days, is he worth keeping at Liverpool just to keep up the numbers?
When Joe Allen replaced the Brazilian, the Reds had so much more poise going forward, an area where Lucas offers very little. But it seems the 27-year-old has also lost his defensive discipline of yesteryear.
Johnson, meanwhile, has frustrated Liverpool fans to no end and now has ample replacements within the squad.
A sale before the transfer deadline could help raise funds and perhaps even aid Rodgers with the signing of a new striker. Napoli have been linked with Lucas throughout the summer, while Harry Redknapp's interest in Johnson earlier this summer suggests the England right-back will have his suitors.
After all, why wait till January when both players look as though their Liverpool futures are under serious threat?
Is time almost up for Lucas and Johnson at Liverpool?