Tottenham's Belgium star is in line to make his first Premier League appearance of the season at White Hart Lane on Sunday.
Not least former manager Harry Redknapp and his coaching staff Glenn Hoddle, Joe Jordan and Kevin Bond. There are also plenty of former players in the Hoops ranks, in Steven Caulker, Bobby Zamora, Jermaine Jenas and Adel Taarabt.
And Belgium international Jan Vertonghen urged caution ahead of the club's second London derby in two Premier League games, emphasising what he sees as plenty of attacking threat up top as one of the major areas of concern.
“They are a very dangerous team with lots of quality and very good strikers,” he said.
“It surprised me a little that they lost at home but they are a strong team and it will be a test. I played against them twice before (2012-13) and they were both difficult games and it will be hard again.”
Vertonghen was happy to make his belated first appearance of the season against AEL Limassol, having missed the opening day win over West Ham as he worked his way back to fitness after Belgium's World Cup campaign.
“It was a hard game to come back into against good opponents,” said the former Ajax man.
“I’m glad we won. It was difficult circumstances for me, my first game back, my first 90 minutes in two months and it was hard, but to win away in Europe is always a good result and I must admit I was happy to get that win.
“We started well, then conceded but we kept playing football. We had to score here, 1-1 would have been a decent result, not perfect, but we won 2-1 and that sets us up for the second leg.”
Vertonghen will be hoping he can get another 90 minutes under his belt on Sunday, and that Spurs will be able to achieve a similar if not even stronger result against their London rivals.
What will the result be when Spurs meet QPR on Sunday?