With Giroud injured and Podolski heading for an Arsenal exit, here are five alternatives from within and on the transfer market who Wenger can turn to.
Arsene Wenger has a selection dilemma with just two Premier League match-days complete in the new 2014-15 season.
Olivier Giroud, who had been earmarked by renowned football analyst Andy Gray as a player capable of leading a title-challenging side like Arsenal, has been sidelined by an ankle injury sustained during the 2-2 draw with Everton at Goodison Park.
According to The Mirror, Arsenal boss Wenger could be forced into the re-entering the transfer market, especially as he may be without another forward, Lukas Podolski, who is expected to seal an Emirates Stadium exit - to Juventus or Galatasaray - this week.
With that in mind, here are five candidates to lead the line for Arsenal if Giroud occupies the physio's room on a long-term basis.
1): Yaya Sanogo
Wenger fielded Sanogo up front during pre-season and has the physical strengths necessary to lead the line in Giroud's absence. Against Benfica, at the start of the month, he smashed four goals past Benfica, prompting supporters to ponder whether he would be ready for increased first-team responsibility this season. His chance, though, may have come earlier than anticipated.
2): Alexis Sanchez
Arsenal's marquee arrival for the summer, erstwhile Barcelona star Sanchez is more adept as an attacker just off - or to the side - of the front-man, but his versatility is such that he could be entrusted with a spear-heading role. His pace alone could threaten slower centre backs and he would be afforded an abundance of chances from the club's creative midfielders.
3): Theo Walcott
Walcott may just be a couple of weeks away from full training and demonstrated last season that he has the capability to be a reliable, title-challenging forward. He has longed for a sustained chance up front and, should Giroud be injured for a number of months, could battle it out with Sanogo in order to make a lasting impression on Wenger, a man who prefers to utilise him high up on the right flank.
4): Joel Campbell
He made an outstanding impression on Gunners fans last season when he spent a year on loan at Olympiacos and even scored against Manchester United in the Champions League. Joel Campbell then underlined his super-prospect status by performing admirably in the World Cup with unfancied Costa Rica. He has been sparingly used by Wenger in pre-season and in competitive football to date, but now his hand may be forced…
5): Edinson Cavani or Loic Remy
If fielding Sanogo, Sanchez, Walcott or Campbell as a lone striker did not inspire confidence in Wenger, then he could turn to Paris Saint-Germain's wantaway player Edinson Cavani, a clinical Uruguayan who craves a lone striker's role - akin to what he received at Napoli, yet at PSG he is shunted to the side in order to accommodate Zlatan Ibrahimovic.
Wenger would likely have to break the club transfer fee record, perhaps even going so far as to equal the fee paid by Manchester United to Real Madrid for Angel di Maria, but in Cavani, they would have one of the most ruthless penalty-box strikers in world football. A cheaper alternative would no doubt be Loic Remy, but would the Queens Park Rangers player pass his medical?
Who would you most want to lead Arsenal's line out of the five listed options?