The 24-year-old signed a four-year deal and was Spurs' sixth signing of the summer in what was another defensive reinforcement as the Frenchman can play across the back four as well as in his preferred defensive midfield role.
He replaces Sandro at Spurs as the Brazilian midfield enforcer left the club after five years to join Harry Redknapp at Queens Park Rangers in a permanent deal.
The man nicknamed 'The Beast' was a fan-favourite at White Hart Lane and his charisma and personality will undoubtedly be missed by supporters and players alike.
He fell down the pecking order in recent months and did not feature in Mauricio Pochettino's plans so Sandro has been replaced by Stambouli in what could be a shrewd piece of business.
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The Frenchman played 20 more games than Sandro last season and outperformed the new QPR man in several key areas.
Stambouli completed more passes per game and also won more headers and tackles per appearance than the Brazilian.
Sandro did make more interceptions per game but it would appear as though Spurs have improved their midfield with the addition of Stambouli.
Sandro is excellent at breaking up play and stopping attacks in the middle of the pitch, but his ability to create anything with the ball hindered Spurs on many occasions.
Stambouli can move the ball on better, and is also strong in the challenge so he could become a regular at Spurs under Pochettino.
Sandro enjoyed five fine years at Spurs and entertained fans during his time with his displays on and off the field, but they have moved him on and replaced him with Stambouli in a piece of business that has left the club in profit once again.
Is Stambouli a good signing for Spurs? Will Tottenham miss Sandro?